Role of Neutrophils, MyD88-Mediated Neutrophil Recruitment, and Complement in Antibody-Mediated Defense against Pseudomonas aeruginosa Keratitis

摘要

The efficacy of a fully human monoclonal antibody to Pseudomonas aeruginosa alginate in preventing infectious and pathologic consequences to the cornea was found to require both PMN and complement for full activity. Neutropenia or an inability to recruit PMN to the eye reduced corneal pathology, but bacterial levels in the tissue were greatly increased with infection spread to the brain and spleen.